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Title | Melanocortin 4 Receptor | Welcome to the MC4R Gene |
Description | MC4R - a key regulator of body Melanocortin 4 Receptor Toggle navigation Introduction Genetics MC4R Deficiency Publications For Patients Contact MC4R - a key regulator of body weight Th |
Keywords | N/A |
WebSite | mc4r.org.uk |
Host IP | 82.163.20.23 |
Location | United Kingdom |
Site | Rank |
US$2,226,170
Last updated: 2023-05-13 02:15:14
mc4r.org.uk has Semrush global rank of 4,754,492. mc4r.org.uk has an estimated worth of US$ 2,226,170, based on its estimated Ads revenue. mc4r.org.uk receives approximately 256,866 unique visitors each day. Its web server is located in United Kingdom, with IP address 82.163.20.23. According to SiteAdvisor, mc4r.org.uk is safe to visit. |
Purchase/Sale Value | US$2,226,170 |
Daily Ads Revenue | US$2,055 |
Monthly Ads Revenue | US$61,648 |
Yearly Ads Revenue | US$739,774 |
Daily Unique Visitors | 17,125 |
Note: All traffic and earnings values are estimates. |
Host | Type | TTL | Data |
mc4r.org.uk. | A | 86398 | IP: 82.163.20.23 |
mc4r.org.uk. | NS | 86400 | NS Record: ns2.phase8.net. |
mc4r.org.uk. | NS | 86400 | NS Record: ns0.phase8.net. |
mc4r.org.uk. | NS | 86400 | NS Record: ns1.phase8.net. |
mc4r.org.uk. | MX | 86400 | MX Record: 30 fwd2.hosts.co.uk. |
mc4r.org.uk. | MX | 86400 | MX Record: 30 fwd1.hosts.co.uk. |
mc4r.org.uk. | MX | 86400 | MX Record: 30 fwd0.hosts.co.uk. |
Melanocortin 4 Receptor Toggle navigation Introduction Genetics MC4R Deficiency Publications For Patients Contact MC4R - a key regulator of body weight The hypothalamus is a key part of the brain that integrates neural and hormonal signals from peripheral organs such as the gut and adipose tissue to regulate body weight. Critically, the hormone leptin, which is produced by adipose tissue, is an indicator of nutritional state. Fasting leads to a fall in leptin which triggers a set of responses in the brain which act to restore energy balance. Leptin acts on neurons within the hypothalamic arcuate nucleus which act as primary sensors of alterations in energy stores. In the fasting state, a fall in leptin stimulates neurons expressing agouti related peptide (AgRP) to increase food intake. At the same time, leptin inhibits POMC neurons, reducing the amount of α-MSH (melanocyte stimulating hormone), which normally suppresses food intake. These signals are integrated by second order neurons |
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